[Excerpt from authors] This paper addresses one of the key global health challenges today, especially in the poorest countries: the influence of the HIV/AIDS epidemic on the health workforce. First, we provide an overview of the impact of HIV/AIDS on health systems and how this influences demand and supply of the health workforce, with a focus on developing countries. Second, we review the impact of HIVAIDS on morbidity and mortality among staff, with specific emphasis on countries in Africa. Next, we review the impact of HIV/AIDS on workforce motivation, performance and migration. Last, we discuss policy options for future staff scenarios and potential obstacles, highlighting policies that could improve retention, replacement and replenishment of health workers.