This technical brief explores the challenges and responses to the retention of health care workers in low-resource settings. [Excerpt from author] Conclusions:While the literature contains evidence-based examples of the magnitude of and causes for turnover, evidencebasedinformation on tested approaches to improve retention remains scarce.Notwithstanding this limitation, anecdotal findings suggest health care managers and organizations should examine three opportunity areas-financial compensation, improving the work environment and strategies to manage migration-in determining which approach or combination of approaches will deliver the greatest potential impact on maintaining a qualified workforce.